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MCF-7 cells, a human breast carcinoma line, forms tumors when injected into athymic nude mice. These tumors are able to metastasize boobies nudes lungs, liver and spleen. Castration or diabetes prevents metastasis formation, but treatment with estrogen or insulin restores the metastasizing capacity. Estrogen or insulin addition to the culture enhances collagenase production.

Attention is called to the coexistence of enhancement in collagenase production and metastasis formation. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. Search: Search.

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Abstract MCF-7 cells, a human breast carcinoma line, forms tumors when injected into athymic nude mice. Similar articles Estrogen and the growth of breast cancer: new evidence suggests indirect action. Shafie SM. PMID: Effect of estrogens and antiestrogens on growth of human breast cancer cells in athymic nude mice.

Osborne CK, et al. Cancer Res. Metastasis of human tumors in athymic nude mice. Sharkey FE, Fogh J. Sharkey FE, et al. Int J Cancer. Influence of melatonin boobies nudes invasive and metastatic properties of MCF-7 human breast cancer cells. Cos S, et al. Hormone sensitivity in vitro and in vivo of v-ras-transfected MCF-7 cell derivatives.

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Van Roy F, et al. See all similar articles. Cheng JN, et al. Clin Exp Metastasis. Epub Dec Wnt5a induces ROR1 to recruit cortactin to promote breast-cancer migration and metastasis. Hasan MK, et al. NPJ Breast Cancer. Ren X, et al. ACS Sens.

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Epub Jul Surfactant functionalization induces robust, differential adhesion of tumor cells and blood cells to charged nanotube-coated biomaterials under flow. Mitchell MJ, et al. Epub Apr A cell-ECM screening method to predict breast cancer metastasis.

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Barney LE, et al. Integr Biol Camb. See all "Cited by" articles. MeSH terms Animals Actions. Castration Actions. Cell Line Actions.

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Female Actions. Humans Actions. Mice Actions. Mice, Nude Actions. Streptozocin Actions. Substances Insulin Actions. Estradiol Actions. Full text links [x] Elsevier Science. Copy Download.

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